The accident also has left at least three people trapped under the passenger bus after the crash.
ER24 spokesperson Vanessa Jackson said the double-decker bus was carrying 80 people and that rescue services were in the process of rescuing the trapped victims of the accident after they are stuck under the under the bus wreckage.
“The scene is chaotic and additional resources have been dispatched, the remaining passengers have minor to moderate injuries,” she told News24.
Jackson said rescue services are currently making efforts to decide which patients require the most urgent care.
Hospitals in the area have been readied to receive multiple patients.
The incident took place at 10:30 on Friday and the bus was the only vehicle involved.
ER24 has confirmed that 10 people have died.